Comparing COVID-19 Vaccines

Additional Information:

• Real world conditions indicate 90% efficacy overall for mRNA vaccines (Pfizer and Moderna).
• There have been 5814 reported breakthrough infections out of over 75 million vaccinated people who were more than 14 days after the 2^nd dose (across all 3 vaccines).
  • 45% were over 60 years of age
  • 65% were women
  • 29% had no symptoms but tested positive
  • 2% (263) were hospitalized due to COVID-19
  • 1% (65) died

References

• The Center for Disease Control
• John Hopkins Coronavirus Resource Center
• Emergency Use Authorization for Vaccines Explained (FDA)
• COVID Vaccine Studies Duke Health
• How vaccines work (CDC)
• More things to know about vaccines (Children’s Hospital of Philadelphia)
• FDA. News Release. FDA and CDC lift recommended pause on Johnson & Johnson (Janssen) COVID-19 vaccine use following thorough safety review. 2021 April 23. https://www.fda.gov/news-events/press-announcements/fda-and-cdc-lift-recommended-pause-johnson-johnson-janssen-covid-19-vaccine-use-following-thorough.
• FP Polack et al. Safety and efficacy of the BNT162b2 mRNA Covid-19 vaccine. N Engl J Med 2020; 383:2603.
• LR Baden et al. Efficacy and safety of the mRNA-1273 SARS-CoV-2 vaccine. N Engl J Med 2021; 384: 403.
• News Release. Johnson & Johnson announces single-shot Janssen COVID-19 vaccine candidate met primary endpoints in interim analysis of its Phase 3 ENSEMBLE trial. https://www.jnj.com/johnson-johnson-announces-single-shot-janssen-covid-19-vaccine-candidate-met-primary-endpoints-in-interim-analysis-of-its-phase-3-ensemble-trial.
• FDA. Fact sheet for healthcare providers administering vaccine. Emergency Use Authorization (EUA) of the Janssen COVID-19 vaccine to prevent Coronavirus Disease 2019 (COVID-19). https://www.fda.gov/media/146304/download.
• MG Thompson et al. Interim estimates of vaccine effectiveness of BNT162b2 and mRNA-1273 COVID-19 vaccines in preventing SARS-CoV-2 infection among health care personnel, first responders, and other essential and frontline workers – eight U.S. locations, December 2020-March 2021. MMWR Morb Mortal Wkly Rep 2021 March 29 (epub).