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Group
Members
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RESEARCH INTERESTS
Project 1: To
date, a detailed understanding of biofilm formation is lacking.
Current models
of the early stages of
biofilm adhesion do not account for chemical reactions that may
occur at the surface
of a substrate.
Our research is focused on
understanding the role of siderophores (organic ligands produced
by most bacteria that have a high binding affinity for iron) in
bacterial adhesion
to metal oxide surfaces.
Project 2: We are also evaluating protective (nonbiofouling) coatings for stainless steel medical implants. Collaborators: Dr. Hazel Barton ![]()
The Bullen Research Group also has a collaborative project with Dr. Haik in investigating the use of custom dendrimers and other nanoparticles for drug delivery across the blood brain barrier (BBB). This project utilizes atomic force microscopy, ATR-FTIR, and UPLC.
Selected Publications (*indicates undergraduates) H. J. Gulley-Stahl,* W. L. Schmidt,* H. A. Bullen. “Characterization and Reactivity of Chromia Nanoparticles prepared by Urea Forced Hydrolysis” Journal of Materials Science 2008, 43, 7066-7072. C. Morris,* B. J. Sieve and H. A. Bullen “E-Learning Module: Introduction to X-ray Diffraction” Journal of the Analytical Sciences Digital Library, 2008, Article ID 100047. (http://www.asdlib.org/onlineArticles/ecourseware/Bullen_XRD/XRDModule_index.htm) C. A. Cason,* S. A. Oehrle, T. Fabre,* C. D. Girten,* K. A. Walters, D. A. Tomalia, K. H. Martines, H. A. Bullen. “Improved Methodology for Monitoring Poly(amidoamine) (PAMAM) Dendrimers Surface Transformations and Product Quality” Journal of Nanomaterials 2008, 2008, Article ID 456082, 1-7.
K. A. Walters, H. A. Bullen. “Development of
a Nanomaterials one Week Intersession Course.” J. Chem. Educ.
2008, 10, 1406. H. A. Bullen. “Teaching Surface Characterization to Undergraduates.” Anal. Bioanal. Chem. 2007, 387, 1579-1581. Selected Presentations (* indicates undergraduates) H. A. Bullen. ‘Utilization of problem-based e-learning modules for undergraduate instruction in analytical chemistry.” 20th Biennial Conference on Chemical Education, Bloomington, IN, July 27-31, 2008. W. Schmidt,* Stephanie Proctor, * H. A. Barton, H. A. Bullen. “Surface analysis of the role of siderophores in biofilm formation.” Pittcon Conference, New Orleans, LA, March 2008. (Poster)
B. Hemmerle,* R. A. Wilson,* H.A.
Barton, H. A. Bullen. “Characterization of Potential Biofouling
Resistant Surfaces on Medical Grade Stainless Steel.” Pittcon
Conference, New Orleans, LA, March 2008. (Poster) W. L. Schmidt,* H. A. Bullen. “Catecholate siderophore complexation on metal oxide surfaces.” ACS National Meeting, Chicago, IL, March 2007. (Poster) R. A Wilson*, H. A. Bullen. “Surface modification of stainless steel medical implants for biofouling prevention.” ACS National Meeting, Chicago, IL, March 2007. (Poster) T. Fabre,* J. Hogan,* K. A. Walters, K. H. Martines, D. A. Tomalia, H. A. Bullen. “Design and characterization of drug delivery systems across the blood brain barrier.” ACS National Meeting, Chicago, IL, March 2007. (Poster) J. Hogan,* T. Fabre,* K. A. Walters, K. H. Martines, D. A. Tomalia, H. A. Bullen. “ATR-FTIR analysis of the interaction of biotinylated dendrimers with blood brain barrier models.” ACS National Meeting, Chicago, IL, March 2007. (Poster) H. A. Bullen, K. A. Walters. “Development of a nanomaterials one week intersession course at NKU.” ACS National Meeting, Chicago, IL, March 2007. (Talk) H. A. Bullen. “Open access peer review port for communicating chemistry: Analytical Sciences Digital Library.” ACS National Meeting, Chicago, IL, March 2007. (Talk) H. A. Bullen, R. A. Wilson, S. Proctor, W. Schmidt, P. J. Hogan, H. J. Stahl, M. Shields. “Probing biofilm formation: spectroscopic and scanning probe microscopy characterization of bacterial adhesion onto metal oxide surfaces.” Pittcon Conference, Chicago, IL, February 2007. (Poster) A. Bennett* H. A. Bullen, and H. A. Barton. “Improved Methods to Relate Metabolic Activities to Biogeochemical Signatures in Carbonate Rock.” CUR Posters at Hill, Washington D. C., April 2006. (Poster)
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