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Robert J. Kempton's Home Page

Robert J. Kempton Regents Professor of Chemistry Email: Kempton@nku.edu Office: SC 450

Chemistry Northern Kentucky University Highland Heights, KY 41099 (859)572-5116

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The courses I'm teaching this semester are:

CHE 310-002 organic chemistry lecture CHE 310L-017 organic chemistry lab (M) CHE 310L-012 organic chemistry lab (T)
Course Number
CHE 310 Organic Chemistry Lecture	310-syllabus.cdx.pdf Previous Exams 310, S08, 1-1.cdx.pdf 310, S08, 1-2.cdx.pdf 310, S08, 1-3.cdx.pdf 310, S08, 1-4.cdx.pdf 310, S08, 2-1.cdx.pdf 310, S08, 2-2.cdx.pdf 310, S08, 2-3.cdx.pdf 310, S08, 2-4.cdx.pdf 310, S08, 3-1.cdx.pdf 310, S08, 3-2.cdx.pdf 310, S08, 3-3.cdx.pdf 310, S08, 3-4.cdx.pdf 310, S08, 4-1.cdx.pdf 310, S08, 4-2.cdx.pdf 310, S08, 4-3.cdx.pdf 310, S08, 4-4.cdx.pdf
CHE 310-L Organic Chemistry lab	Organic Chemistry Laboratory. Information about the lab is available on the department’s website.
CHE 310-L Organic Chemistry lab	Syllabus-Mon lab.cdx.pdf Syllabus_Tues_Lab.cdx.pdf

Research Interest

Folic acid (1) is a vitamin which in its reduced form is involved in several cellular one-carbon transfer reactions, among them the conversion of 2'-deoxyuridine-5'-monophosphate (dUMP) into 2'-deoxythymidine-5'-monophosphate (dTMP).  Methotrexate (2), first introduced clinically in 1953 and still widely used in cancer chemotherapy, acts by inhibiting dihydrofolate reductase, the enzyme required for the reduction of folic acid.  My students and I are working on the synthesis of a number of analogues of Methotrexate.  Compound 3, an N-10 deaza analogue of Methotrexate, has recently been prepared in our laboratories.

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